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Showing posts with label Hashimoto's thyroiditis. Show all posts
Showing posts with label Hashimoto's thyroiditis. Show all posts

Friday, 4 April 2025

Hashimoto's thyroiditis- What's in a name?

This paper is ultimately confusing.

I agree with abandoning the eponym Hashimoto's thyroiditis. (Though, at least in the abstract of the paper, the eponym Ord's thyroiditis isn't even recognised.)

But I strongly disagree with the assertion that we should not test for thyroid autoantibodies, and we should avoid imaging. Another case of ensuring that by not looking, you won't find?

In common with many other diseases/disorders, it might be useful to subdivide "autoimmune thyroiditis" and/or "autoimmune thyroid disease" into those with various antibodies or other features. And you also need to include those who are hypothyroid despite not having been diagnosed with either of the classic antibodies.

I very much question how many asymptomatic people are ever diagnosed and treated. Rather, I suspect that numerous signs and symptoms are missed/ignored as they are not recognised as the classic indicators of autoimmune thyroid disease - or, indeed, non-autoimmune thyroid disease. After all, we see multiple posts by HealthUnlocked forum members who have what appear euthyroid results for the TSH test (often the only test), and Free T4, and (if ever done) Free T3. This is part of the course of the disease for many. A variation of thyroid hormone levels, with possibly unclear other symptoms, and potentially over years.

And it bizarrely tells us not to use the word "disease", then discourages the use of the word when only tests and imaging show the issues, but gives no replacement word? How about "autoimmune thyroid not yet recognised as disease"?

Hashimoto's thyroiditis- What's in a name?

Mikhail Khachaturov  1 , Dimitrios G Goulis  2 , Petros Perros  3

    PMID: 40172784 DOI: 10.1007/s42000-025-00646-2

Abstract

Hashimoto's thyroiditis (HT) is the most common autoimmune endocrine disease worldwide with an annual incidence of 0.3-1.5 per 1000 people and a prevalence of 8% of the general population. At least nine terms appear in the literature denoting HT, which are used as synonyms or are terms describing disorders closely related to HT. Moreover, the definitions of HT vary, and the role of several parameters in making a diagnosis remains unclear. Furthermore, the term "thyroiditis" is often used among experts to describe the triphasic evolution in thyroid status (thyrotoxicosis, hypothyroidism, and euthyroidism) that can occur not only after some forms of HT but also in other causes of thyroid inflammation. The present work proposes novel approaches for the nomenclature problems. Firstly, we should abandon the eponym "Hashimoto" in keeping with recent trends. The void left can be replaced by the terms "autoimmune thyroiditis" or "autoimmune thyroid disease", which are already in use. In communicating among ourselves and with patients, it is imperative and good practice to provide, whenever possible, context to these terms by specifying whether they apply to thyroid status, presence or absence of goiter, thyroid autoantibodies, imaging, cytology/histology, epidemiology, or etiology. Secondly, the considerable potential harm associated with treating euthyroid people with thyroid hormones could be curtailed by avoiding testing for thyroid autoantibodies or performing thyroid imaging in asymptomatic euthyroid patients following the current guidelines and by discouraging the use of the word "disease" when the evidence is based only on results of investigations, such as positive antibodies, or imaging.

Keywords: Definition; Endocrinology; ICD-11; Immunology; Nomenclature; Pathology; Radiology.

https://link.springer.com/article/10.1007/s42000-025-00646-2

Mendelian randomization reveals causal effect of Hashimoto's thyroiditis on immune thrombocytopenic purpura

There are towards a dozen or so posts on the HealthUnlocked Thyroid UK forum ( https://healthunlocked.com/thyroiduk/ ) which mention "purpura", "immune thrombocytopenic purpura", "idiopathic thrombocytopenic purpura" or "immune thrombocytopenia". And I suspect numerous other which do not use these formal terms - or mention petechiae, etc.

Hence this paper on the association/relationship of Hashimoto's Thyroiditis and purpura seems potentially of interest and relevance.

DermNet NZ, as so often, provides a good description of and introduction to Purpura, if you need it:

https://dermnetnz.org/topics/purpura

Mendelian randomization reveals causal effect of Hashimoto's thyroiditis on immune thrombocytopenic purpura

ABSTRACT
Introduction

Patients with immune thrombocytopenic purpura (ITP) usually express thyroid antigen-specific antibodies. The purpose of this study was to explore the causal relationship between Hashimoto's thyroiditis (HT) and ITP.
Methods

A two-sample Mendelian randomization (TSMR) analysis was applied to investigate the potential causal relationship between HT and ITP in European population. Five complementary methods including inverse variance weighted (IVW), Mendelian Randomization-Egger (MR-Egger), weighted median, and weighted mode were performed in our study. Risk genes of HT and ITP were selected through Mendelian randomization (MR), and the common risk genes were further analysed by bioinformatics methods to explore the common pathogenesis of the two diseases.
Results

The MR analysis revealed a potential causal relationship between HT and risk of ITP [odds ratio (OR) = 1.22; 95% confidence interval (CI) 1.01, 1.49; P = 0.046]. Gene eQTL data were obtained from the IEU database. HT and ITP were respectively treated as outcome variables for MR analysis, and a total of 32 common risk genes were selected, including 12 high-risk genes and 20 low-risk genes. Functional analysis including Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genome (KEGG) analysis revealed that risk genes were closely related to antigen processing and presentation, and played a crucial role in the process of various viral and bacterial infections.
Conclusion

Our study demonstrated that HT may increase the risk of ITP, and revealed the role of their common risk genes in the development of the two diseases.

Full paper currently accessible here:

https://www.tandfonline.com/doi/10.1080/16078454.2025.2484959

(The PDF is not currently accessible.)

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