helvella - Bed-time dosing of levothyroxine

It is often suggested that bed-time dosing results in slightly better absorption. It also seems slightly closer to the pattern healthy people have.

I have always taken my levothyroxine at bed-time.

For that reason, I cannot compare with taking in the morning.

Before diagnosis, my sleep was badly disturbed. Typically, I would fall asleep fairly easily. Then wake up after something like half an hour to two hours. Once woken I'd be unable to get back to sleep - often till dawn, or at all.  

Once I started on levothyroxine, my sleep slowly improved. By the time I was taking an adequate dose, bad nights were unusual - just an occasional night where I might wake up for a while. Now, after years, I sleep very easily and deeply and rarely wake at all. If I do, I get back to sleep quickly. 

We have some who prefer it; we have others who prefer other times. See our poll:

https://healthunlocked.com/thyroiduk/polls/133674000/when-do-you-take-your-thyroid-medication

Some papers which discuss taking levothyroxine at different times - such as bed-time. There are many other papers which discuss timing - this is just a sample.

Levothyroxine Replacement and Ramadan Fasting

https://pubmed.ncbi.nlm.nih.gov/23776910/

Effect of L-Thyroxine Administration Before Breakfast vs at Bedtime on Hypothyroidism: A Meta-Analysis

https://pubmed.ncbi.nlm.nih.gov/32022947/

Morning vs. Bedtime Levothyroxine Administration: What Is the Ideal Choice for Children?

https://pubmed.ncbi.nlm.nih.gov/30312169/

A Crossover Study Evaluating Effect of Timing of Levothyroxine on Thyroid Hormone Status in Patients of Hypothyroidism

https://pubmed.ncbi.nlm.nih.gov/31321928/

Effect of Timing of Levothyroxine Administration on the Treatment of Hypothyroidism: A Three-Period Crossover Randomized Study

https://pubmed.ncbi.nlm.nih.gov/30043093/

Alternative Schedules of Levothyroxine Administration

https://pubmed.ncbi.nlm.nih.gov/25694412/

Thyroid Diseases and Ramadan

https://pubmed.ncbi.nlm.nih.gov/22837909/

Pharmacotherapy: Hypothyroidism-Should Levothyroxine Be Taken at Bedtime

https://pubmed.ncbi.nlm.nih.gov/21364516/

Effects of Evening vs Morning Levothyroxine Intake: A Randomized Double-Blind Crossover Trial

https://pubmed.ncbi.nlm.nih.gov/21149757/

Timing of Levothyroxine Administration Affects Serum Thyrotropin Concentration

https://pubmed.ncbi.nlm.nih.gov/19584184/

Effects of Evening vs Morning Thyroxine Ingestion on Serum Thyroid Hormone Profiles in Hypothyroid Patients

https://pubmed.ncbi.nlm.nih.gov/17201800/

Evaluation of Bedtime vs. Morning Levothyroxine Intake to Control Hypothyroidism in Older Patients: A Pragmatic Crossover Randomized Clinical Trial

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261378/

Previous posts:

Levothyroxine - Switching to night

https://healthunlocked.com/thyroiduk/posts/147630388/levothyroxine-switching-to-night

Levothyroxine Medication Query

https://healthunlocked.com/thyroiduk/posts/148163682/levothyroxine-medication-query?responses=148165773

 

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[i][b]helvella - Bed-time dosing of levothyroxine [/b]

Discussion about taking levothyroxine at bed-time. Several linked references to relevant papers.[/i]

https://helvella.blogspot.com/p/helevlla-bed-time-dosing-of.html 

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