Welcome - again!

This might be the first time you have ever seen my blog. In which case, just welcome. For returnees, welcome again.

I keep adding pages to the main content of my blog - the numerous pages are indexed here: 

Index of Blog Pages

https://helvella.blogspot.com/p/helvella-index-of-blog-pages.html

A recently added page identifies what tests might be included in an Iron Panel or a Thyroid Panel. While the phraseology of "ordering a panel" sounds very American, it has become ever so common. Yet the simplest level of knowing what that means is rarely explained.

And I keep adjusting the phrasing, adding some words, correcting typos, etc. 

You might ask, why does helvella put things on a blog rather than on HealthUnlocked's Thyroid UK forum?

https://healthunlocked.com/thyroiduk

There are several reasons. But they include:

I can include much more information than in a reply on the forum.

I can include multiple graphics.

My replies on the forum can be tailored to the individual's actual question and circumstances. Putting a lot into a reply can feel overwhelming and confusing. And, if appropriate, I can add a link to my blog for more information.

Posting the same information repeatedly is tedious for other members.

I simply cannot write the information out every time someone asks. So I have to store it somewhere. By making that place a blog, it allows anyone to access my stored information at any time - at their convenience.

I can put more effort into a blog than into replies. That includes making the replies more comprehensive, including references, etc.

At the same time, this blog does not replace the forum. It is intended to add to it.

 

 

 

Information from manufacturer Eli Lilly:

Mounjaro ^® (tirzepatide) injection

2.5 mg/5 mg/7.5 mg/10 mg/12.5 mg/15 mg

Full Prescribing Information

This information is provided in response to your request. Resources may contain information about doses, uses, formulations and populations different from product labeling. See Prescribing Information above, if applicable.

Can people take Mounjaro® (tirzepatide) with levothyroxine?

Levothyroxine is not contraindicated with the use of tirzepatide; however, tirzepatide delays gastric emptying and thereby has the potential to impact the absorption of concomitantly administered oral medications like levothyroxine.

See important safety information, including boxed warning, in the attached prescribing information.

Use With Levothyroxine

Levothyroxine is not contraindicated with the use of tirzepatide.1

Tirzepatide delays gastric emptying and thereby has the potential to impact the absorption of concomitantly administered oral medications. The impact of tirzepatide on gastric emptying was greatest after a single dose of 5 mg and diminished after subsequent doses.1

Monitor patients on oral medications dependent on threshold concentrations for efficacy and those with a narrow therapeutic index (NTI) when concomitantly administered with tirzepatide.1

The Food and Drug Administration (FDA) has concluded that levothyroxine is a NTI drug.2-4

Eli Lilly and company does not provide specific treatment recommendations. We strongly encourage patients to go to their healthcare provider for treatment advice because they know their patient's medical history the best.

The prescribing information for levothyroxine includes a warning for worsening of diabetic control: Therapy in patients with diabetes mellitus may worsen glycemic control and result in increased antidiabetic agent or insulin requirements. Carefully monitor glycemic control after starting, changing, or discontinuing thyroid hormone therapy.4

Enclosed Prescribing Information

MOUNJARO® (tirzepatide) injection, for subcutaneous use, Lilly

References

1Mounjaro [package insert]. Indianapolis, IN: Eli Lilly and Company; 2023.

2US Food and Drug Administration (FDA). Draft Guidance on Levothyroxine Sodium. Updated December 2014. Accessed August 16, 2023. https://www.accessdata.fda.gov/drugsatfda_docs/psg/Levothyroxine%20sodium_draft_Oral%20tab_RLD%20021116%20%20%20%20%20%20%20%20%20%20%20%20%20%20021210%20%20%20%20%20%20%20%20%20%20%20%20%20%20021301%20%20%20%20%20%20%20%20%20%20%20%20%20%20021342%20%20%20%20%20%20%20%20%20%20%20%20%20%20021402_RC12-14.pdf

3US Food and Drug Administration (FDA). Real-world Evidence from a Narrow Therapeutic Index Product (Levothyroxine) Reflects the Therapeutic Equivalence of Generic Drug Products. Updated November 19, 2020. Accessed August 16, 2023.

4Synthroid [package insert]. North Chicago, IL: AbbVie Inc; 2017.

Date of Last Review: August 14, 2023

https://medical.lilly.com/us/products/answers/can-people-take-mounjaro-tirzepatide-with-levothyroxine-199579

USA FDA's DailyMed link:

 MOUNJARO- tirzepatide injection, solution

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d2d7da5d-ad07-4228-955f-cf7e355c8cc0

Few blogs - Many pages

I don't often post blog entries.

What I tend to do is post pages which are meant to be for reference - rather than the frequent blogs. Most blogs are intended to promote something or other. (And that is not in itself a criticism.) Or to provide an ongoing narrative.

Whereas my main aim is to maintain what could be pages on a website.

You can see the index to all my blog pages here:

https://helvella.blogspot.com/p/helvella-index-of-blog-pages.html

There are ordered alphabetically by title - within sections. And I regularly update them.

If you find anything wrong or out of date - please let me know!